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Abstract
The present study investigated whether the administration of amlodipine ameliorates oxidative stress induced by experimental myocardial infarction in rats. Adrenaline was administered and myocardial damage was evaluated biochemically [significantly increased serum aspertate aminotransferase (AST), lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels of myocardial tissue] and histologically (morphological changes of myocardium). Amlodipine was administered as pretreatment for 14 days in adrenaline treated rats. Statistically significant amelioration in all the biochemical parameters supported by significantly improved myocardial morphology was observed in amlodipine pretreatment. It was concluded that amlodipine afforded cardioprotection by reducing oxidative stress induced in experimental myocardial infarction of catecholamine assault.
Highlights
Cardiovascular diseases (CVDs) are the major health problem of advanced as well as developing countries of the world (Debashis et al, 2004)
There was a marked rise in serum lactate dehydrogenase (LDH) level in the adrenaline treated group as compared to vehicle and the rise was highly significant (p
The change in serum LDH level in only amlodipine or alcohol treated group when compared to vehicle was not statistically significant
Summary
Cardiovascular diseases (CVDs) are the major health problem of advanced as well as developing countries of the world (Debashis et al, 2004). In Bangladesh CVD is an emerging health problem. Prevalence study in our country is few. In one survey Mohibullah et al (1998) studied the pattern of CVDs for a period of 1992-97 in a local hospital, Dhaka. They concluded that all types of cardiac diseases are found in Bangladesh. Hypertension is the common cardiac disease followed by ischemic heart disease (IHD). In 2002, the WHO estimated that 12.6% of deaths worldwide were from IHD
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