Abstract
<p>The present study reveals the protective effect of<em> Garcinia pedunculata</em> aqueous fruit extract in isoprenaline-induced myocardial infarction in Wistar rats. Isoprenaline (200 mg/kg) administration subcutaneous once daily for two consecutive days significantly (p&lt;0.01) increased the CK-MB, AST, ALT, ALP activity and CRP (p&lt;0.05) levels. Pretreatment with extract (400 mg/kg) orally for 14 consecutive days significantly ameliorated the effect of isoprenaline by reducing the activity of CK-MB and the levels of ALP, SGPT respectively. No significant changes were seen in the case of SGOT activity and CRP levels. Severe necrotic lesions in the myocardial tissue were observed in isoprenaline-treated group. In extract-treated group, mild degenerative changes of myo-cardial tissues to nearly normal cytoarchitecture were seen. The results indicate the cardioprotective effect of <em>G. pedunculata</em> against isoprenaline- induced myocardial infarction rat model.</p><p> </p>
Highlights
Myocardial infarction is the acute ischemic condition where profound necrosis of myocardial tissue occurs
Fruits of G. pedunculata were collected from Assam region, India with the help of a botanist during March of 2012
The concentrated extract of G. pedunculata was used for the isoprenaline-induced cardioprotective activity
Summary
Myocardial infarction is the acute ischemic condition where profound necrosis of myocardial tissue occurs. This mainly results of imbalance between coronary blood supply and myocardial oxygen demand (de Bono et al, 1992). Isoprenaline undergoes auto-oxidation and generate highly cytotoxic free radicals These free radicals stimulate per-oxidation of membrane phospholipids causing severe damage to myocardial membrane. The inflammation event takes place with infiltration of neutrophils into the infarcted area where it can promote myocardial cell damage through the release of proteolytic enzymes. It intern produces cytotoxic reactive oxygen species (Kannan and Quine, 2013). The model is used as a novel method to produce myocardial infarction in experimental animals
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