Cardioprotection with a BKCa channel activator improves post-ischemic cardiac recovery in pigs and normalizes altered mitochondrial protein expression assessed by TMT-MS.

Wenzhuo Ma,Zhiqi Zhang,Frank Sellke,Clarissa Cavarsan,Jun Feng,Scarlett Huck,Martin Kolodziejczak,Dmitry A Terentyev,Richard T Clements,Neel Sodha,Afshin Ehsan

doi:10.1016/j.bpj.2022.11.717

Cardioprotection with a BKCa channel activator improves post-ischemic cardiac recovery in pigs and normalizes altered mitochondrial protein expression assessed by TMT-MS.

Wenzhuo Ma, Zhiqi Zhang + Show 9 more

https://doi.org/10.1016/j.bpj.2022.11.717

Copy DOI

Journal: Biophysical journal

Publication Date: Feb 1, 2023

Affiliation: Providence College, Rhode Island Hospital, University of Rhode Island, The Ohio State University, Rhode Island College

#BKCa Channel Activation #Mild-ischemic Insults + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

We and others have demonstrated that activation of the BKCa channel is mitigates myocardial stunning associated with mild-ischemic insults. Cardioprotective BKCa channel activation is associated with decreased ROS, improved respiration, and survival. In this study we used pig model of myocardial stunning due to cardioplegic arrest and cardiopulmonary bypass (CP/CPB). Mitochondrial protein expression alterations were identified by TMT-MS analysis.

Full Text