Cardiomyocyte Maturation During Regeneration

Abstract

The interplay between calcium signaling and sarcomeres plays a crucial role in directing cardiomyocyte maturation during cardiac regeneration. During cardiac regeneration, various processes occur to restore damaged or lost cardiac tissue, including the proliferation and differentiation of precursor cells into functional cardiomyocytes. These newly formed cardiomyocytes undergo a maturation process to acquire the structural and functional characteristics of adult cardiomyocytes. Nguyen and colleagues found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. A component of the cardiac dyad called leucine-rich repeat-containing 10 (Lrrc10) acted as a negative regulator of proliferation, prevented cardiomegaly, and induced redifferentiation. They found that its function was conserved in mammalian cardiomyocytes. Their study highlights the importance of the underlying mechanisms required for heart regeneration and their application to the generation of fully functional cardiomyocytes. Science. 2023 May 19;380(6646):758-764. doi: 10.1126/science.abo6718.