Abstract
Introduction: Cell-cycle progression critical for de novo cardiomyocyte formation is rare and poorly characterized in postnatal mammalian heart. Novel insights of cardiomyocyte cell-cycle dynamics can be revealed using Fluorescence Ubiquitination-based Cell-Cycle Indicator (FUCCI) system, showing inverse oscillation of cell-cycle fusion proteins AzGr-hGeminin (AzGr) and mKO2-hCdt1 (mKO). FUCCI was specifically expressed via tissue-specific transgenesis to reveal cardiomyocyte cell cycle status and define mitotic progression.
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