Cardiometabolic Risk in Hyperlipidemic Men and Women.

Michael Leutner,Silvia Charwat-Resl,Jürgen Harreiter,Helmut Prosch,Alexandra Kautzky-Willer,Alice Wielandner,Eleonora Howorka,Christian Göbl,Marlies Prünner,Latife Bozkurt,Oliver Schlager

doi:10.1155/2016/2647865

Michael Leutner, Silvia Charwat-Resl + Show 9 more

Open Access

https://doi.org/10.1155/2016/2647865

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Abstract

Objective. The aim of this study was to evaluate sex specific differences of metabolic and clinical characteristics of treated hyperlipidemic men and women (HL-men and HL-women). Methods. In this study vascular and metabolic characteristics of 35 HL-women and 64 HL-men were assessed. In addition a sex specific analysis of metabolic and nutritional habits of HL-patients with prediabetes (HL-IGR) was done. Results. HL-women were older and had favourable concentrations of high density lipoprotein cholesterol (HDL-cholesterol), triglycerides (TG), and triglyceride/HDL-cholesterol ratio (TG/HDL-ratio) but were also shown to have higher concentrations of lipoprotein-a compared to HL-men. HL-men were characterized as having higher levels of liver-specific parameters and body weight as well as being more physically active compared to HL-women. Brain natriuretic peptide (pro-BNP) was higher in HL-women than HL-men, while no differences in metabolic syndrome and glycemic parameters were shown. HL-IGR-women were also older and still had a better profile of sex specific lipid parameters, as well as a lower body weight compared to HL-IGR-men. No differences were seen in vascular parameters such as the intima media thickness (IMT). Conclusion. HL-women were older and had overall more favourable concentrations of lipid parameters and liver enzymes but did not differ regarding vascular morphology and insulin sensitivity compared to HL-men of comparable body mass index (BMI).

Highlights

In general men have a higher risk of cardiovascular mortality compared to women [1]
We show that HLwomen were older and had a lower body weight and waist circumference but did not differ regarding body mass index (BMI) and the systolic and diastolic blood pressure compared to HL-men
HL-women are characterized as being older and having a lower body weight and waist circumference, more favourable concentrations of HDL-cholesterol, TG, and TG/HDL-ratio, and better concentrations of liver enzymes, but they do not differ regarding insulin sensitivity and the intima media thickness (IMT) compared to HL-men

Summary

Introduction

In addition to the better outcome in cardiovascular disease (CVD) in women, the time of occurrence of CVD is later [2]. These discrepancies occur due to the significant influence that sex plays on the development of CVD [1]. One of the major influences on CVD is the lipid profile [3, 4] and it is well known that there are sex specific differences in the progression of CVD affected by hyperlipidemia [5, 6]. Studies show that there are sex specific differences in the reach of target values of lipid parameters. Wenger showed that hyperlipidemic men reach more often the target values of blood parameters compared to women [8]

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Results

Conclusion