Abstract
Men with early-onset androgenetic alopecia are characterized by hormonal profiles similar to those observed in women with polycystic ovary syndrome. The purpose of this research was to investigate levels of cardiometabolic risk factors in 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)-treated men with early-onset androgenic alopecia. We studied two matched rosuvastatin-treated groups of men with mixed dyslipidemia: subjects with early-onset androgenic alopecia (group A) and subjects with normal hair growth (group B). Plasma lipids, glucose homeostasis markers, and levels of sex hormones, uric acid, hsCRP, homocysteine, fibrinogen, and 25-hydroxyvitamin D were measured before entering the study and six months later. Both groups differed in insulin sensitivity and levels of calculated bioavailable testosterone, dehydroepiandrosterone-sulfate, uric acid, hsCRP, fibrinogen, and 25-hydroxyvitamin D. Though observed in both study groups, treatment-induced reductions in total cholesterol, LDL cholesterol, hsCRP, and fibrinogen were more pronounced in group B than group A. Moreover, only in group A did rosuvastatin deteriorate insulin sensitivity, and only in group B did the drug affect uric acid, homocysteine, and 25-hydroxyvitamin D. The impact of rosuvastatin on cardiometabolic risk factors correlated with insulin sensitivity, calculated bioavailable testosterone, and dehydroepiandrosterone-sulfate. The obtained results suggest that men with early-onset androgenic alopecia may benefit to a lesser degree from rosuvastatin treatment than their peers.
Highlights
Accepted: 10 May 2021The presence of polycystic ovary syndrome (PCOS) in women is associated with an increased arterial stiffness, increased carotid intima-media thickness, endothelial dysfunction, thrombotic complications, cerebrovascular events, and possibly cardiovascular events [1]
A very similar hormonal profile to that observed in male siblings of women with PCOS was reported in men with early-onset androgenic alopecia
Cholesterol, high-density lipoproteins (HDL) cholesterol, triglycerides, glucose, estradiol, and homocysteine. Both groups differed in HOMA1-IR and levels of calculated bioavailable testosterone, DHEA-S, uric acid, high-sensitivity C-reactive protein (hsCRP), and fibrinogen, which were higher in group A than in group B, as well as in 25-hydroxyvitamin D, which was higher in group B than in group A (Tables 1 and 2)
Summary
The presence of polycystic ovary syndrome (PCOS) in women is associated with an increased arterial stiffness, increased carotid intima-media thickness, endothelial dysfunction, thrombotic complications, cerebrovascular events, and possibly cardiovascular events [1]. Compared with brothers of healthy women, brothers of women with PCOS are characterized by increased levels of two-hours post-challenge glucose, increased values of insulin resistance markers, and higher values of systolic blood pressure, as well as higher prevalences of impaired glucose tolerance, metabolic syndrome, and type 2 diabetes [2,3,4,5,6,7,8]. It is reasonable to assume that male relatives of PCOS probands should be screened, identified, and appropriately treated [9,10]. The classic male-pattern of hair loss involves the temporal and vertex region while leaving a rim of hair at the sides and sparing the Published: 11 May 2021
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