Abstract
Background: Cardio-metabolic risk and clinical presentation profile in obstructive sleep apnea (OSA) differs between men and women. Objective: To evaluate the influence of gender on OSA-related symptoms and prevalent cardio-metabolic disease in the European Sleep Apnea Database (ESADA) cohort. Methods: We identified a sample of 18,872 patients (mean age 52 years, 30% women) from the ESADA cohort with complete data from polygraphic or polysomnographic recordings and Epworth sleepiness scale (ESS). The predictive value of gender on associated symptoms and prevalent cardio-metabolic disease was investigated after adjustment for relevant confounding factors including age, obesity and comorbidities. Results: Arterial hypertension [odds ratio, OR (95% CI) 1.493 (1.336–1.660), p 16) [OR (95% CI) 1.356 (1.198–1.536), p 30 min) [OR (95% CI) 1.739 (1.576–1.920), p Conclusion: In this large clinical patient cohort, cardio-metabolic comorbidities were more prevalent in female compared to male OSA patients. Furthermore, women with OSA are more likely to complain about EDS and report symptoms suggestive for insomnia.
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