Abstract
Transplantation experiments in mice reveal that the increased risk of congenital heart disease in the pups of older mothers is not conferred by ageing eggs, but by the mothers' age, and can be mitigated by exercise. See Letter p.230 Patrick Jay and colleagues investigate the known increased risk of congenital heart disease with increased maternal age. By transplanting ovaries between young and old mice they establish that the maternal age-associated risk of congenital heart disease in pups harbouring a mutation of the cardiac transcription factor gene Nkx2-5 is independent of the age of the ovaries and depends on the age of the mother. They further show that maternal exercise can mitigate this age-associated risk, although the mechanisms at work are not yet known.
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