Abstract
Psychotropic drugs can produce cardiovascular side effects associated with a degree of cardiotoxicity. The coexistence of a heart disease complicates the management of mental illness, can contribute to a reduced quality of life and a worse illness course. The co-occurrence of psychiatric disorders in cardiac patients might affect the clinical outcome and morbidity. Moreover, the complex underlying mechanism that links these two conditions remains unclear. This paper discusses the known cardiovascular complications of psychotropic drugs and analyzes the important implications of antidepressive treatment in patients with previous cardiac history.
Highlights
The World Health Organization has defined an adverse drug reaction as “a response to a drug that is noxious and unintended and occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of disease, or for modification of physiological function”
The judgment of the physician is continuously needed, health professionals need to be aware of the evidence pertaining to differences in side effects, clinical characteristics of the patient should be evaluated withdrawing all unsuitable medications and attention should be paid to the knowledge of possible undesirable reaction in order to practice preventive strategies might help to reduce the risk of adverse drug reactions
Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed. They are effective, but because of their side effects and drug interaction, MAOIs have historically been reserved as a last line of treatment, used only if other classes of antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), are not helpful.[55]
Summary
The World Health Organization has defined an adverse drug reaction as “a response to a drug that is noxious and unintended and occurs at doses normally used in man for the prophylaxis, diagnosis or therapy of disease, or for modification of physiological function”. The fact that psychotropic drugs have various cardiovascular effects may negatively affect clinical outcome of cardiac patients. Marano G et al Cardiologic side effects of psychotropic drugs the physician have to be very scrupulous in the prescription management, and it is necessary to pay attention to undesirable reaction ensuring that patients receive therapeutic benefits. The judgment of the physician is continuously needed, health professionals need to be aware of the evidence pertaining to differences in side effects, clinical characteristics of the patient should be evaluated withdrawing all unsuitable medications and attention should be paid to the knowledge of possible undesirable reaction in order to practice preventive strategies might help to reduce the risk of adverse drug reactions
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