Abstract
Cardiolipin-cholesterol interactions were studied by time-resolved fluorescence spectroscopy with 1,6-diphenyl-1, 3,5-hexatriene as probe. The residual anisotropy parameter, r ∞ (reflecting the fatty acid chain packing), was measured in the liquid crystalline phase as a function of cholesterol addition. Two main results are reported: (i) a slight increase of the order parameter, S, computed from the r ∞ value as S = ( r ∞/ r 0) 1 2 , in the physiological concentration range of cholesterol; (ii) a sharp enhancement of S from a cholesterol mole fraction ( X̄ chl) of 0.20 and up to X̄ chl of 0.80. This is in contrast to unsaturated kcithin systems for which a continuous increase of the order parameter was monitored, culminating at X̄ chl = 0.50, the wellknown maximum level of incorporation of cholesterol into lecithin model membranes.
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