Abstract
<strong>Background:</strong>Terminalia arjuna is being used in various cardiovascular diseases as cardiotonic, diuretic&amp;in hypercholesterolemia. Studies conflict each other for its mechanism of action. This study aims to investigate effect of 90% alcoholic extract of Terminalia arjuna on in vitro isolated rabbit's heart&amp;to find its probable mechanism of action.<p><strong>Objective:</strong> To study the preliminary pharmacological effects of 90% alcoholic extract of Terminalia arjuna in-vitro on isolated heart, coronary blood flow, and to study its probable mechanism of action.</p><p><strong>Material&amp;Methods:</strong> Effect of Terminalia arjuna was observed on heart rate, coronary blood flow, amplitude on in vitro isolated perfused rabbit's heart mounted on langendorff apparatus&amp;further cholinergic&amp;adrenergic blockers were used to study the mechanism of action. Six experiments were conducted for each parameter&amp;data was analysed using Student's t test.</p><p><strong>Results:</strong> Terminalia arjuna causes mean percentage decrease of 7.26%, 9.31%&amp;20.51% in heart rate, decrease of 10.34%, 16.64%, 20.51% in coronary blood flow&amp;decrease of 15.11%, 12.61%, 11.65% in amplitude at 25μg, 50μg&amp;100μg doses respectively. The decrease in heart rate, coronary blood flow&amp;amplitude persists even after cholinergic&amp;adrenergic blockers suggesting that cholinergic&amp;adrenergic receptors are not involved in mechanism of Terminalia arjuna.</p><p><strong>Conclusion:</strong> Terminalia arjuna cardiodepressant effect does not involve cholinergic&amp;adrenergic receptors.</p>
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