Abstract
In a group of 60 patients with trophoblastio tumours, 52 had pulmonary metastases and these caused serious symptoms in 12 patients. Six patients presented with cardio-respiratory symptoms, and four of these had no symptoms of a gynaecological nature. Three main forms of pulmonary metastases have been distinguished. The commonest metastasis is the easily recognized discrete mass. This is normally asymptomatic, but confluent growth may progress to a fatal respiratory acidosis. Miliary metastitio involvement of the lungs is the least common form, and may be associated with hyperventilation and tachycardia. Tumour emboli of sufficient size, number, or growth potential to occlude the pulmonary arteries cause pleuritio pain, dyspnoea, hyperventilation, signs of pulmonary hypertension, and large pulmonary arterio-venous shunts. Gross functional disturbances may be corrected by specific chemotherapy.
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