CARDIO-PULMONARY PROFILE IN LIMITED AND DIFFUSE SYSTEMIC SCLEROSIS.

Abstract

Background: Scleroderma, systemic sclerosis (SSc), is a chronic multisystem autoimmune disease characterized by a vasculopathy, diffuse brosis of skin and numerous internal organs, and immune abnormalities. The clinical manifestations of this disease are extremely heterogeneous.1 Pulmonary and cardiac involvement of scleroderma are responsible for signicant morbidity and mortality.2 This study aims to evaluate and compare different cardiac and pulmonary manifestations between limited and diffuse systemic sclerosis. Materials And Methods: 54 Systemic Sclerosis patients were studied at Assam Medical College and Hospital, from June 2020 to May 2021. In our study Results: among 54 patients, 46 were female (85.19%) and male (14.81%). Maximum (40.74%) patients were between the age group 41-50 years. 53.70% had diffuse and 46.30% had limited cutaneous systemic sclerosis. Dyspnoea on exertion (59.26%), cough (35.19%) and palpitation (20.37%). Dyspnea was signicantly higher in diffuse SSc (75.86%) compared to limited SSc (40%). 72.22% of the studied population had ILD. Predominant HRCT ndings were ground glass opacity (53.70%). 2D-ECHO abnormalities were observed in (62.96%) patients of diffuse SSc (72.41%); 58.62% of diffuse and 44% of limited cutaneous disease had abnormal ECG. PAH was observed in 28% in limited and 13.79% in diffuse Ssc. Conclusion: From this study we can conclude that though systemic manifestations and organ involvement was more common in diffuse SSc. Thorough evaluation in cases of SSc is essential for early diagnosis, treatment & better prognostic outcome