Abstract
Psychiatric and cardio-metabolic conditions are commonly comorbid and a leading global cause of disability. Early adversity increases risk for both conditions, however, biological pathways remain unknown. The dopamine (DA) system is highly sensitive to early adversity and implicated in the development of these comorbidities. We investigated if individual variations on the expression of a mesocorticolimbic-DA gene network moderates the effect of early adversity on risk for psychiatric and cardio-metabolic comorbidities.
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