Abstract
WCN 2013 No: 1259 Topic: 36 — Other Topic Cardioand cerebrovascular risk is associated with decreased slow wave sleep in patients with chronic kidney disease A.V. Lindner, K. Ronai, K. Fornadi, A.S. Lazar, M.E. Czira, A. Dunai, R. Zoller, O. Veber, A. Szentkiralyi, Z. Kiss, E. Toronyi, M.Z. Molnar, I. Mucsi, M. Novak. Department of Neurology, Semmelweis University, Budapest, Hungary; Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary; Amgen Hungary Limited, Semmelweis University, Budapest, Hungary; Dept. of Transplantation and Surgery, Semmelweis University, Budapest, Hungary; Division of Nephrology, University of Toronto, Toronto, ON, Canada; Los Angeles Biomedical Research Institute at Harbor, UCLA, Torrance, CA, USA; Institute of Pathophysiology, Semmelweis University, Budapest, Hungary; Division of Nephrology, McGill University, Montreal, QC, Canada; Dept. of Psychiatry, University of Toronto, Toronto, ON, Canada Background: Previous studies reported that sleep fragmentation and decreased slow wave sleep related to certain cardiovascular risk factors e.g. cholesterol levels, obesity in general population. Objective: Our study aims to analyze association between cardioand cerebrovascular risk and slow wave sleep in patients with chronic kidney disease. Patients and methods: 100 kidney transplanted and 50 wait-listed hemodialyzed patients underwent polysomnography. The ten-year coronary heart disease risk was estimated for all patients using the Framingham Score. Moreover, the ten-year estimated risk of stroke was calculated according to the modified version of the Framingham Stroke Risk Profile. In multivariate linear regression models logarithmic transformed Framingham scores were used for estimating association between slow wave sleep and cardiocerebrovascular risk. Results: Mean age was 51 ± 13 yrs, ratio of males was 56% in the population. Slow wave sleep was reverse related to cardiovascular and stroke risk (Spearman's rho: 0.259, p = 0.003; −0.209, p = 0.011). In multivariate linear regression models the lower ratio of slow wave sleep was independently associated with the logarithmic transformed Framingham cardiovascular (beta =−0.211; 95% CI: −0.45 to −007) and cerebrovascular scores (beta =−0.155; 95% CI: −0.033–0.0) after adjusting for important co-variables (apnea–hypopnea index, serum albumin and hemoglobin levels, type of renal replacement, Charlson comorbidity index, sleep efficiency). Conclusion: Decreased slow wave sleep was found to be an independent predictor of higher cardioand cerebrovascular risk score in patients with chronic kidney disease. doi:10.1016/j.jns.2013.07.2299 Abstract — WCN 2013 No: 673 Topic: 36 — Other Topic Is transient global amnesia (TGA) hereditary? WCN 2013 No: 673 Topic: 36 — Other Topic Is transient global amnesia (TGA) hereditary? M.M. Dupuis, F. Evrard, S. De Bruijn, J. Segers-van Rijn, F. Dupuis, P. Jacquerye, G. Picard, O. Ghysens, K. Dahan, C. Verellen. Clinique St Pierre, Ottignies, Belgium; Neurology, Hagaziekenhuis, Den Haag, The Netherlands; Institut de Pathologie et de Genetique,
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