Abstract
The fundamental pathophysiologic perturbations in heart failure (HF) with preserved ejection fraction (HFnlEF) remain controversial. Recent data have suggested that LV end diastolic (LVED) volume (vol) may be increased in HFnlEF, implying vol overload without diastolic dysfunction as a pathophysiologic mechanism in HFnlEF. These studies, however, were limited by selection bias. These issues were addressed in this community-based study. Methods: Three groups were studied; subjects without cardiovascular disease or obesity (Normals: n = 617; 45% male; age 57 ± 9 (range 45–96)); subjects with hypertension but no HF (HTN; n = 719; 44% male; age 66 ± 10 (range 46–91)); and pts with HFnlEF (n = 252; 42% male; age 77 ± 13 (range 22–99)).
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