Abstract
ObjectiveThe aim of this study was to assess the results of troponin I (cTnI) in non- acute Coronary Syndrome (ACS) patients with chronic kidney disease (CKD). We also examined the risk factors for elevated cTnI in non-ACS patients with CKD and whether stage 5 CKD modifies the associations of elevated cTnI and the risk factors in non-ACS patients with CKD.MethodsA retrospective study was performed. Logistic regression models were used.Results293 non-ACS patients with CKD were included in the current study. 43.34% non-ACS patients with CKD have an elevated cTnI level and 5.12% have an elevated cTnT level in MI range. In CKD patients without ACS and heart failure, only 26.03% (38/146) patients have an elevated cTnT level. In adjusted analyses, age, diastolic blood pressure and congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD (OR 2.30, 95% CI 1.08,4.88, P=0.03). Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level.Conclusion43.34% non-ACS patients with CKD and 26.03% CKD patients without ACS and congestive heart failure have an elevated cTnI level. Congestive heart failure is associated with an elevated cTnI level in non-ACS patients with CKD. Stage 5 CKD does not modify the association of congestive heart failure and an elevated cTnI level.
Highlights
Cardiac troponin T and cardiac troponin I have been shown to be highly sensitive and specific markers of myocardial cell injury [1,2]
CTnI determinations were done for 368 patients in the department of nephrology, of which 12 patients were diagnosed as acute kidney injure, 12 patients had no chronic kidney disease (CKD), and other 51 patients were excluded because of chest pain or ST segment elevation or pathologic Q wave formation in ECG. 293 non-acute coronary syndromes (ACS) patients with CKD were included in the current study
Stage 5 CKD does not modify the association of congestive heart failure and an elevated cardiac troponin I (cTnI) level
Summary
Cardiac troponin T (cTnT) and cardiac troponin I (cTnI) have been shown to be highly sensitive and specific markers of myocardial cell injury [1,2]. Previous studies have indicated that cTnT may be elevated in patients with chronic renal failure in the absence of ischemic heart disease [3]. There is a paucity of data on cardiac troponin I (cTnI) measured by a high sensitivity assay in CKD patients without detectable acute coronary syndromes (ACS). The aim of this study was to assess the results of cTnI in non-ACS patients with CKD. We examined the risk factors for elevated cTnI in non-ACS patients with CKD and whether stage 5 CKD modifies the associations of elevated cTnI and the risk factors in non-ACS patients with CKD
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