Cardiac-specific inactivation of LSD1 in mice leads to myocardial hypertrophy and heart failure

Abstract

Histone lysine specific demethylase 1(LSD1), an important epigenetic regulator, can specifically demethylates mono- and dimethylation of histone 3 lysine 4 (H3K4me1 and me2) and H3K9me1 and me2. Although the modifications of histone lysine methylation, through JMJD2A, KDM3A and PHF8, have been reported to play a critical role in cardiac hypertrophy and failure, the significance of LSD1 in cardiac remodeling and fibrosis has not been directly evaluated in vivo.