Abstract
Late cardiac toxicity following combined modality therapy is a major concern in the treatment of pediatric Wilms’ Tumor patients. Cardiac exposure to radiation can increase the risk of valvular dysfunction, congestive heart failure, arrhythmias, and myocardial infarction in pediatric patients. Significance of this effect can potentially enhance the cardiotoxic effects of adriamycin, frequently used to treat this disease. For whole abdominal irradiation in Wilms’ Tumor, parallel-opposed fields are used which delivers the prescription dose to portions of the left ventricle.
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