Cardiac resynchronization therapy restored ventricular septal myocardial perfusion and enhanced ventricular remodeling in patients with nonischemic cardiomyopathy presenting with left bundle branch block

Abstract

Left bundle branch block (LBBB) causes intraventricular conductional delay, which results in left ventricle (LV) mechanical dyssynchrony. In the absence of coronary artery disease, patients with LBBB often have diminished accumulation of technetium-99m compounds at the myocardial septal area in electrocardiogram-gated single-photon emission computed tomography. To investigate whether cardiac resynchronization therapy (CRT) could improve septal myocardial perfusion, leading to favorable reverse remodeling. The study included all 26 patients with nonischemic cardiomyopathy eligible for CRT, who presented with LBBB, New York Heart Association class II-IV heart failure, and LV ejection fraction ≤35%. Single-photon emission computed tomography was performed at baseline and 6 months after CRT. Perfusion counts were measured at the ventricular septum and LV lateral free wall. Left ventricular end-systolic volume (LVESV) was measured by echocardiography to evaluate LV reverse remodeling by CRT. At baseline, a perfusion defect at the LV septal myocardial area was confirmed in 19 of 26 (73%) patients. In these patients, septal perfusion significantly increased 6 months after CRT (56.1% ± 22.8% vs 82.9% ± 21.2%; P < .001). LVESV reduction and improved septal perfusion index were positively correlated (r = .561; P = .012), whereas no correlation was found between LVESV reduction and the difference of QRS duration before and 6 months after CRT (r = .218; P = .371). The improvement in LV septal perfusion was associated with LV reverse remodeling. CRT could restore LV septal myocardial perfusion and ameliorate ventricular reverse remodeling in most patients with nonischemic cardiomyopathy and LBBB.