Abstract
Ten canine hearts undergoing perfusion with 200 to 300 ml. of clinical dextran containing 15% DMSO during extracorporeal support maintained the circulation acutely and seven supported life beyond the acute period. The seven long-term survivors maintained their weight, evidenced normal activity, and had unremarkable electrocardiographic tracings. Light microscopy demonstrated a significant myocardial lesion in the surviving heart perfused with the most dextran-DMSO, which may have been related to electrical defibrillation. Electron microscopy revealed no definite abnormalities. Catecholamine content of the myocardium was moderately reduced. Myocardial analysis for electrolytes, fat, carbohydrates, and various glycolytic and citric acid cycle enzymes revealed no major deviations from normal.
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