Cardiac output and oxygen uptake relationship during physical effort in men and women over 60 years old

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This study investigated the relationship between oxygen uptake (VO(2)), cardiac output (Q), stroke volume (SV), and heart rate (HR) in 54 men and 77 women (age = 69 +/- 5 years) during incremental effort. Subjects performed a maximal cycle-ergometer test and VO(2) was directly measured. HR and SV were assessed by ECG and cardiograph impedance. Regression equations were calculated for Q-VO(2), HR-VO(2), and Q-HR relationships. The equations obtained for women were (a) Q (l min(-1)) = 2.61 + 4.67 VO(2) (l min(-1))(r(2) = 0.84); (b) HR (bpm) = 62.03 + 46.55 VO(2) (l min(-1)) (r (2) = 0.72); (c) SV (ml) 100:6[1 - e(-2.6 VO2 (1 min-1))] (r (2) = 0.41); (d) HR (bpm) = 41.48 + 9.24 Q (l min(-1)) (r (2) = 0.73). Equations for men were (a) Q (l min(-1)) = 2.52 + 5.70 VO(2) (l min(-1)) (r (2) = 0.89); (b) HR (bpm) = 66.31 + 32.35 VO(2) (l min(-1)) (r (2) = 0.72); (c) [1 - e(-1.7 VO2 (1 min-1))] (r (2) = 0.47); (d) HR (bpm) = 56.33 + 5.25 Q (l min(-1)) (r (2) = 0.69). The intercepts for Q-VO(2) and HR-VO(2) equations were similar for both genders, but the slopes were different (P < 0.05). The SV increased from baseline to 50-60% of VO(2) peak in both groups. No gender effect was found in SV increasing pattern, but the absolute values were in general higher for men (P > 0.05). A significant difference between men and women was observed for both slopes and intercepts in the Q-HR relationship (P < 0.05). In conclusion, (a) Q-VO(2) relation was linear during progressive effort; (b) regression intercepts were similar, but the slopes were higher for men compared to women; (c) SV-VO(2) relationship was nonlinear and maximum SV was reached at very submaximal workload; (d) older men exhibited higher Q upward potential as well higher SV but lower HR for a given submaximal workload than women of similar age.