Abstract
Cardiac natriuretic peptides, atrial and brain natriureticpeptides (ANP and BNP, respectively) are known to haveanti-cardiac hypertrophy effects. ANP and BNP bind totheir common receptor, guanylyl cyclase-A, which subse-quently activates cGMP-protein kinase G (PKG) pathway.Precise molecular mechanisms by which cardiac natriu-retic peptides protect hearts against pathological cardiachypertrophy still remain unclear, however. Transientreceptor potential (TRP) C6, an ion channel responsiblefor the receptor-activated Ca2+ entry, has been shown tobe a positive regulator of calcineurin-NFAT signalingpathway that drives pathologic cardiac remodeling [1]. Inthis study to elucidate the molecular pathways, by whichcardiac natriuretic peptides negatively regulate pro-hyper-trophic signaling, we investigated effects of ANP onTRPC6-calcineurin-NFAT signaling.
Highlights
Cardiac natriuretic peptides, atrial and brain natriuretic peptides (ANP and BNP, respectively) are known to have anti-cardiac hypertrophy effects
4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S1-info.pdf
In this study to elucidate the molecular pathways, by which cardiac natriuretic peptides negatively regulate pro-hypertrophic signaling, we investigated effects of ANP on TRPC6-calcineurin-NFAT signaling
Summary
Atrial and brain natriuretic peptides (ANP and BNP, respectively) are known to have anti-cardiac hypertrophy effects. Address: 1Department of Medicine and Clinical Science, Kyoto University Graduated School of Medicine, Kyoto, Japan, 2Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, Fukuoka, Japan, 3Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, 4Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan and 5EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan * Corresponding author from 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Regensburg, Germany.
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