Abstract
Prolonged occlusion of the coronary arteries can lead to ischemic heart failure (IHF). Molecular changes within the myocardium during IHF are not fully understood. Accordingly, we aimed to characterize the biophysical properties of myocardial contractile proteins in IHF. Ten age-matched human males with similar BMI were included in the study. Cardiac biopsies of left ventricular free wall were taken from patients with ischemic heart failure (IHF, n=5) at the time of heart transplant or from organ donors with no previous history of ischemic heart failure (controls, n=5).
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