Abstract
Background Hypoxia induces pulmonary vasoconstriction leading to an increase in pulmonary vascular resistance and acute pulmonary hypertension (PH). It is known that with acute hypoxia, cardiac output (CO) is maintained with an increase in heart rate (HR) but a blunted stroke volume (SV) response. To our knowledge, the response of the healthy heart to acute pulmonary hypertension has not been studied using exercise cardiac magnetic resonance imaging (CMR). CMR is a highly reproducible and accurate method of evaluating biventricular function during exercise and can be used to measure real time physiological response to an increased cardiovascular workload. We aimed to study the ability of exercise magnetic resonance imaging to detect changes in right ventricular (RV) and left ventricular (LV) function during normoxic and hypoxic exercise.
Highlights
Hypoxia induces pulmonary vasoconstriction leading to an increase in pulmonary vascular resistance and acute pulmonary hypertension (PH)
We aimed to study the ability of exercise magnetic resonance imaging to detect changes in right ventricular (RV) and left ventricular (LV) function during normoxic and hypoxic exercise
Median peripheral oxygen saturation decreased from 98% at to 87.5% at rest and 79.5% on exercise At rest, there was no significant difference between stroke volume (SV) during normoxia and hypoxia (97+/-32 mL vs 105+/-41 mL), there was a significant increase in resting heart rate (HR) (57+/-9 vs 69+/-10 bpm) (p = 0.03) and cardiac output (CO) (5.2+/-1.4 L/min vs 6.5+/-1.9 L/min) (p = 0.03)
Summary
Hypoxia induces pulmonary vasoconstriction leading to an increase in pulmonary vascular resistance and acute pulmonary hypertension (PH). It is known that with acute hypoxia, cardiac output (CO) is maintained with an increase in heart rate (HR) but a blunted stroke volume (SV) response. The response of the healthy heart to acute pulmonary hypertension has not been studied using exercise cardiac magnetic resonance imaging (CMR). CMR is a highly reproducible and accurate method of evaluating biventricular function during exercise and can be used to measure real time physiological response to an increased cardiovascular workload. We aimed to study the ability of exercise magnetic resonance imaging to detect changes in right ventricular (RV) and left ventricular (LV) function during normoxic and hypoxic exercise
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
