Cardiac L-Type Channel Modulation by LRRC10 Proteins

Abstract

L-type calcium channels (LTCC) play a central role in cardiac physiology by conveying Ca2+ influx that initiates cardiac muscle contraction following membrane depolarization. LTCC activity is fine-tuned by diverse regulatory subunits, and alterations in channel regulation cause debilitating cardiac diseases. Importantly, leucine-rich repeat containing protein 10 (LRRC10) was recently identified as a novel regulatory subunit of cardiac LTCC (Woon et al (2018) JAHA 7:e006528). Mutations in LRRC10 have been identified in patients with dilated cardiomyopathy (DCM) and sudden unexplained nocturnal death syndrome (SUNDS).