Abstract
Endogenous cardiac hyaluronidase activity of early developing embryonic hearts was examined qualitatively and semiquantitatively at the time when mesenchymal cushion cells begin to migrate into cardiac jelly to form endocardial cushion tissue. Although the extract of five hearts from stage 17 to 18 embryos showed extensive hyaluronidase activity, isolated cushion tissue from nine hearts of similar stages did not show any noticeable activity within the limit of the sensitivity of the present technique. Moreover, the extract of 24 pairs of isolated atrio-ventricular cushions from stages 21 to 23 hearts revealed only a trace of hyaluronidase activity. Hyaluronidase activity was observed in the homogenized ventricular apices from similar hearts. The ventricular apex is primarily myocardium and does not contain cushion tissue. These results suggest that the observed high endogenous cardiac hyaluronidase activity is primarily myocardial in origin. Therefore, the appearance of high enzyme activity may not be functionally associated with the proliferation and migration of cushion cells but possibly with morphogenetic process of the myocardial wall.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
