Abstract
Background Hypertension (HPT) is an important risk factor for heart disease worldwide. It is already established that in hypertension there is an abnormal oxygenation response to stress (by exploiting the paramagnetic properties of deoxyhemoglobin, blood oxygen level-dependent, BOLD). Additionally, abnormal resting cardiac energetics (phosphocreatine/adenosine triphosphate, PCr/ATP, as measured by 31Phosphorus MR Spectroscopy, 31P MRS) has been reported. However, it is not known if this energetic profile worsens with the increasing energy demand of exercise, and if so, if the blunted Oxygen supply response may contribute to this. Understanding this relation can lend new insights into the pathophysiology and management of hypertensive heart disease. We hypothesized that cardiac energetic are abnormal at rest and are further impaired during acute exercise in HPT, and that this impairment is related to abnormal oxygenation during stress.
Highlights
Hypertension (HPT) is an important risk factor for heart disease worldwide
We hypothesized that cardiac energetic are abnormal at rest and are further impaired during acute exercise in HPT, and that this impairment is related to abnormal oxygenation during stress
There was a significantly reduced BOLD SIΔ response in HPT (BOLD SIΔ: 10 ± 2%; normal 20 ± 0.01% P = 0.004)
Summary
Cardiac energy metabolism and oxygenation during exercise in the hypertensive heart Sairia Dass1,2*, Rina Ariga, Emily Sever, Lowri E Cochlin, Joseph Suttie, Cameron Holloway, Masliza Mahmod, Theodoros D Karamitsos, Stefan Neubauer. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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