Abstract
The antiparkinson drugs, etybenztropine, prophenamine and benzhexole, the local anesthetic drug lidocaine, and the tranquilizing drug chlorpromazine were added to the recirculating medium in a rat heart perfusion apparatus. All the drugs caused the following effects: (a) A dose-dependent decrease in impulse generation and impulse conducting velocity. (b) A dose-dependent decrease in cardiac contractility. (c) A dose-dependent decrease in coronary flow preceded by an increase at lower concentrations. (d) A dose-dependent decrease in potassium loss from the hearts, followed by an increase at higher concentrations. An additive effect of chlorpromazine and etybenztropine on cardiac contractility was found. It is concluded that the changes in ECG cardiac contractility and coronary flow in the isolated perfused rat heart induced by antiparkinson drugs and local anesthetics are similar to those produced by tranquilizing phenothiazine derivatives. It is further suggested that the effects can be explained as secondary to a decrease in cell membrane permeability.
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