Abstract
BackgroundDiabetes is a major risk factor for cardiovascular disease. In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. The functional abnormalities of diabetic myocardium have been attributed to the pathological changes of diabetic cardiomyopathy.MethodsIn this study, we used high field magnetic resonance imaging (MRI) to evaluate the left ventricular functional characteristics of streptozotocin treated diabetic Sprague-Dawley rats (8 weeks disease duration) in comparison with age/sex matched controls.ResultsOur analyses of EKG gated cardiac MRI scans of the left ventricle showed a 28% decrease in the end-diastolic volume and 10% increase in the end-systolic volume of diabetic hearts compared to controls. Mean stroke volume and ejection fraction in diabetic rats were decreased (48% and 28%, respectively) compared to controls. Further, dV/dt changes were suggestive of phase sensitive differences in left ventricular kinetics across the cardiac cycle between diabetic and control rats.ConclusionThus, the MRI analyses of diabetic left ventricle suggest impairment of diastolic and systolic hemodynamics in this rat model of diabetic cardiomyopathy. Our studies also show that in vivo MRI could be used in the evaluation of cardiac dysfunction in this rat model of type 1 diabetes.
Highlights
IntroductionType 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis
Diabetes is a major risk factor for cardiovascular disease
Diabetic cardiomyopathy (DCM) is characterized by a cascade of myocardial changes that occurs in diabetes mellitus with fibrosis, hypertrophy and microcirculatory abnormalities
Summary
Type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. Diabetic cardiomyopathy (DCM) is characterized by a cascade of myocardial changes that occurs in diabetes mellitus with fibrosis, hypertrophy and microcirculatory abnormalities. These cardiovascular complications compromise cardiac performance resulting in cardiac failure. DCM is marked by diastolic dysfunction early in the disease progression [2,3,4], with its reported occurrence even in patients with well-controlled diabetes in the absence of (page number not for citation purposes). In addition reports suggest subtle systolic dysfunction later during the course of diabetes that evades detection with echocardiography [2]. It has been suggested that detection of systolic dysfunction might require highly sensitive techniques [3]
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