Cardiac Depressant Activity of Erythrina variegata Linn on Isolated Frog- Heart

Karthikeyan R,Koushik Os

doi:10.4172/2472-0992.1000107

Abstract

Objective: Erythrina variegata Linn of the family leguminaceae is a medium sized deciduous small tree with prickly stems and branches, leaves with triangular leaflets and large coral red flowers and grows all over Bangladesh. Different parts of E. variegata have used in traditional medicine as nervine sedative, febrifuge, anti-asthmatic and antiepileptics.It is having the d-tubacurarine like activity. The present study was under taken to evaluate the cardiac depressant activity of Erythrina variegata in experimental animal model. Materials and method: Aqueous extract of E. variegata was tested for cardiac depressant action by using frog isolated heart model. Different concentration of atropine sulphate is used along with plant water extract. Results: The water extract shows the significant cardiac depressant activity. Conclusion: The present study shows that E. variegata has significant cardiac depressant activity.

Highlights

The Erythrina variegate Linn (Leguminaceae) is a medium sized deciduous small tree with prickly stems and branches, leaves with triangular leaflets and large coral red flowers and grows all over Bangladesh [1,2]
The present study shows that E. variegata has significant cardiac depressant activity
Different extracts of leaves of Erythrina variegata were evaluated for Different concentrations of extracts reveal that the activity of Erythrina variegata leaves on cardiovascular system via heart rate, force of contraction and tone level

Summary

Introduction

The Erythrina variegate Linn (Leguminaceae) is a medium sized deciduous small tree with prickly stems and branches, leaves with triangular leaflets and large coral red flowers and grows all over Bangladesh [1,2]. Conclusion: The present study shows that E. variegata has significant cardiac depressant activity. The root extracts of Erythrina variegate Linn. Erythrina variegate Linn showed significant anti malarial activity in vitro toward Plasmodium falciparum using the lactate dehydrogenase (LDH) method.

Results

Conclusion