Abstract
Patients with short bowel syndrome (SBS) on long-term home parenteral nutrition (HPN) chronically receive high fluid volumes directly into the right atrium (RA) through the superior vena cava. We retrospectively evaluated cardiac function measured by routine transthoracic echocardiography (TTE) in a population of 26 SBS patients on long-term HPN and compared their data on echocardiograph-derived right heart structure and function, with those of a control group of 26 patients also bearing a central venous catheter (CVC) for other reasons. Results showed that body weight and BMI were significantly higher in the control group. The echocardiographic estimate of RA pressure was higher in HPN patients than in controls (p = 0.01). An increased estimate of RA pressure indicates the need to consider TTE in the follow-up of long-term HPN patients to detect functional impairment early.
Highlights
In clinical practice, the right atrium (RA) and right ventricle (RV) are less often considered than the other two cardiac chambers, and their role in cardiac pathophysiology remains insufficiently explored [1,2]
19.71 ± 3.86 kg/m2 ) with short bowel syndrome (SBS) who were on long-term home parenteral nutrition (HPN) were evaluated; 26 age- and sex-matched patients (11 M, 15 F, 50.54 ± 17.24 years, 62.50 ± 12.47 kg, BMI 22.83 ± 4.03 kg/m2 ) bearing a central venous catheter for chemotherapy were used as control subjects
Diastolic blood pressure was lower in HPN patients (p = 0.02)
Summary
In clinical practice, the right atrium (RA) and right ventricle (RV) are less often considered than the other two cardiac chambers, and their role in cardiac pathophysiology remains insufficiently explored [1,2]. Patients with short bowel syndrome (SBS) on long-term home parenteral nutrition (HPN). In the long term, this fluid overload could exert a significant influence on the structure and function of right chambers. To the best of our knowledge, the possible hemodynamic changes of the right heart in patients with SBS undergoing long-term HPN have not been investigated. The present retrospective study was designed to analyze the right heart chamber phenotype of SBS patients on long-term HPN in comparison with a control population bearing a central venous catheter (CVC) for oncologic reasons
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