Abstract
Cirrhotic cardiomyopathy (CCM) is a term used to define a constellation of characteristics that illustrate abnormal cardiac structure and function in patients with cirrhosis. These encompass systolic and diastolic dysfunction, electrophysiological and structural anomalies, both macroscopic and microscopic. At present, the prevalence of CCM remains unknown, mostly because the condition is typically latent and becomes noticeable when the patient is under stress, like exercise, drugs, hemorrhage or surgery. The essential clinical attributes of CCM consist of elevated baseline cardiac output, abnormal response of systolic contraction and diastolic relaxation as an answer to physiological, pharmacological or surgical stress and electrical anomalies (prolonged QT interval). In most cases, diastolic dysfunction predates systolic dysfunction, which tends to manifest only under stressful conditions. CCM diagnosis is still challenging, due to an absence of specific criteria. The prognosis is, as well, difficult to establish, but the severity of the diastolic dysfunction can be a risk marker for mortality.
Highlights
Cardiac abnormalities in hepatic cirrhosisAlexandru MIHAILOVICI1 MD, Gabriel VILCEANU2 MD, Lecturer Ionut DONOIU3 MD, PhD, Assoc
During the evolution of hepatic cirrhosis, the patients develop a slow decline of both the cardiac and circulatory functions, the latter being described for the first time by Kowalsky et al [1], Murray et al [2], more than 60 years ago
In the last two decades, it has been proved that cardiac dysfunction is present in non-alcoholic cirrhosis and it is characterized by a decreasing cardiac contractility as an answer to diverse stimuli
Summary
Alexandru MIHAILOVICI1 MD, Gabriel VILCEANU2 MD, Lecturer Ionut DONOIU3 MD, PhD, Assoc. Cirrhotic cardiomyopathy (CCM) is a term used to define a constellation of characteristics that illustrate abnormal cardiac structure and function in patients with cirrhosis. These encompass systolic and diastolic dysfunction, electrophysiological and structural anomalies, both macroscopic and microscopic. The essential clinical attributes of CCM consist of elevated baseline cardiac output, abnormal response of systolic contraction and diastolic relaxation as an answer to physiological, pharmacological or surgical stress and electrical anomalies (prolonged QT interval). Diastolic dysfunction predates systolic dysfunction, which tends to manifest only under stressful conditions. The prognosis is, as well, difficult to establish, but the severity of the diastolic dysfunction can be a risk marker for mortality
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