Carcinosarcoma of the prostate: clinical observation and literature review

Abstract

Carcinosarcoma is a rare type of prostate neoplasms and accounts for less than 1 % of all malignant tumors of the prostate. This kind of tumor is characterized by the absence of prostate-specific antigen elevation in most cases, which leads to diagnosis of metastatic disease in a quarter of patients. Moreover, carcinosarcoma of the prostate has an extremely poor clinical prognosis. From the morphological point of a view, biphasicity is a typical feature for these tumors. As a rule, epithelial component is represented by poorly differentiated acinar adenocarcinoma. However, in some literature cases adenogenous component was represented by ductal or neuroendocrine carcinoma. Sarcoma component can be represented by any sarcoma type. Currently, pathogenesis of carcinosarcomas isn’t clear. In this report, we describe a clinical case of carcinosarcoma of the prostate in a 72-year-old male.