Abstract
AbstractHepatitis C virus (HCV) is a hepatotropic RNA virus capable of establishing acute and chronic infections in humans. In the majority of cases, HCV induces persistent infections leading to chronic hepatitis, associated to various degrees with necrotic-inflammatory activity and hepatic fibrosis. The main complications are cirrhosis and hepatocellular carcinoma (HCC), responsible for almost 270,000 deaths a year world-wide.The development of potent, well-tolerated antiviral therapies and the availability of new virological tools have revolutionized management of hepatitis C infection. In line with the objectives of the World Health Organization (WHO), there is an urgent need to simplify and expand screening and diagnosis of HCV infection, simplify the cascade of care and increase access to antiviral treatment.
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