Abstract
A significant decrease in 5-year survival was found in 265 patients with invasive cervical cancer under the age of 35 compared to 820 over the age of 35 in all stages except Stage I-A and Stage IV. The exact reasons for the differences remain obscure. The greatest number of failures occurred in Stage II-B patients where, despite central control of disease, distant metastases developed. This suggests that the pretreatment evaluation of younger patients, especially those with Stage II-B cancer, should be more aggressive at attempts to detect cancer beyond the usual treatment fields. The poorer prognosis for patients under age 35 could not be explained on the basis of cell type. It was found that patients with large-cell, keratinizing cancers had a somewhat improved survival over patients with large-cell, non-keratinizing cancers.
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