Abstract

<p>Carcinoma of the middle ear is a rare otologic disease. The development of malignancy is most commonly associated with chronic inflammation of the middle ear, although the mechanisms of this development have not been clarified yet. The symptoms of the carcinoma are not always specific and the cancer is frequently diagnosed in its advanced stage. Early evidence-based diagnosis implies a thorough evaluation and identification of cancer signs and symptoms. If ear discharge is followed by an intensive pain, bleeding from the ear, occurrence of peripheral facial nerve palsy, vertigo and hearing loss, the carcinoma is suspected, although similar clinical symptoms may be recognized in chronic otitis media as well. In addition, the characteristic signs and symptoms of carcinoma are also the following: changes in temporomandibular joint, parotid gland swelling, painless solitary mastoid swelling, neurological disorders, sudden occurrence of polyps and granulation tissue (recurrent polyps and granulation tissues after the removal), signs and symptoms of otogenic complications, as well as generalized weakness, weight loss and other biological disturbances. The diagnostic approach may include generally accepted recommendations and treatment protocols.</p>

Highlights

  • Akademija medicinskih nauka Srpskog lekarskog društva, Beograd Klinički centar Srbije, Klinika za otorinolaringologiju i maksilofacijalnu hirurgiju, Beograd Univerzitet u Beogradu, Medicinski fakultet, Beograd, Srbija

  • the cancer is frequently diagnosed in its advanced stage

  • If ear discharge is followed by an intensive pain

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Summary

Kratak sadržaj

Nastanak malignog procesa se uzročno-posledično najčešće povezuje s hroničnim zapaljenskim procesima srednjeg uva, mada mehanizmi nastanka još uvek nisu sasvim razjašnjeni. Parsons i Lewis [5] su prikazali mogućnosti hirurškog lečenja malignih tumora srednjeg uva i temporalne kosti. Često je teško odrediti da li maligni tumor počinje da se razvija iz spoljnjeg slušnog hodnika ili iz šupljine srednjeg uva. Karcinom srednjeg uva brzo infiltrira medijalne delove spoljnjeg slušnog hodnika, a maligni tumor koji polazi s kože unutrašnjeg dela hodnika brzo zahvata cavum timpani. U ovom radu smo na osnovu našeg iskustva i podataka iz literature prikazali povezanost hroničnih otitisa i pojave malignog procesa i ukazali na osnovne principe dijagnostike i terapije karcinoma srednjeg uva. Planocelularni karcinom (squamous cell carcinoma) jeste najčešći epitelijalni tumor srednjeg uva i javlja se u 70-80% svih drugih malignih tumora ove regije [15]. To su veoma retki tumori, a biološki spadaju u veoma agresivne tumore

Klinička slika
Carcinoma of middle ear Dragoslava Djerić
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