Abstract
Introduction: Mixed adenoneuroendocrine carcinomas (MANEC) are types of biphasic tumors, morphologically recognized in the presence of a neoplastic formation constituted simultaneously by glandular epithelium and neuroendocrine cells. Only 19 cases located in the ampulla of Vater have been reported in the literature. Within the gastrointestinal tract, these neoplasms predominate in the stomach or colon. Aim: Report a case of MANEC; review of the epidemiology, prognosis and treatment of these tumors. Materials and Method: Case presentation of a patient diagnosed with mixed adeno-neuroendocrine carcinoma of the ampullary region. Discussion: The clinical presentation, management and prognosis are similar to ampullary adenocarcinoma. These tumors are diagnosed with a histopathological examination of the resected specimen. Both components must be histologically malignant, and each of them must represent at least 30% of the lesion. Conclusion: MANEC of the ampulla are rare tumors worldwide, being this case the first reported in our institute.
Highlights
Mixed adenoneuroendocrine carcinomas (MANEC) are types of biphasic tumors, morphologically recognized in the presence of a neoplastic formation constituted simultaneously by glandular epithelium and neuroendocrine cells
Paciente de género femenino de 60 años de edad sin antecedentes de relevancia, acude a la consulta por dolor abdominal en hipocondrio derecho, alza térmica e ictericia, acompañada de coluria y acolia
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report
Summary
Mixed adenoneuroendocrine carcinomas (MANEC) are types of biphasic tumors, morphologically recognized in the presence of a neoplastic formation constituted simultaneously by glandular epithelium and neuroendocrine cells. Aim: Report a case of MANEC; review of the epidemiology, prognosis and treatment of these tumors. Discussion: The clinical presentation, management and prognosis are similar to ampullary adenocarcinoma. These tumors are diagnosed with a histopathological examination of the resected specimen. Introducción: Los carcinomas adenoneuroendocrinos mixtos (MANEC) son tipos de tumores bifásicos, reconocidos morfológicamente ante la presencia de una formación neoplásica constituida de manera simultánea por epitelio glandular y células neuroendocrinas. Materiales y Método: Presentación de caso clínico de una paciente con diagnóstico de adenocarcinoma neuroendocrino mixto de la región ampular. Conclusión: Los MANEC ampulares son tumores poco comunes a nivel mundial, siendo éste el primer caso reportado en nuestro instituto. El carcinoma adenoneuroendocrino mixto (MANEC, por sus siglas en inglés) es una patología rara. Según los registros se ha observado mayor incidencia en estómago, vesícula, páncreas y colon, siendo la localización en duodeno muy rara[4,5]
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