Abstract
An overview of carcinogenesis risk assessment is presented. The nature of evidence for carcinogenic potential in humans is discussed, including possible carcinogenic mechanisms, genotoxicity and laboratory animal data. Emphasis is given to the importance of including all pertinent evidence in risk assessment, rather than placing total reliance on mathematical extrapolations from animal tumour data. An approach to ranking animal carcinogens according to the weight of evidence is described briefly.
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