Abstract
PP-29-034 Background/Aims: Between November 2008 and January 2009, the study aimed to assess urinary 8-OHdG and lung function of 28 traffic policemen exposure to ambient fine particulate matter (PM) in Hsinchu area in Taiwan. Methods: The subjects were monitored for 2 days to assess integrated 10-hour PM2.5 breathing zone concentration. Personal PM2.5 concentration was collected from personal air samplers, and the metal content was analyzed by inductively coupled plasma mass spectroscopy method. Urinary 8-OHdG was analyzed by liquid chromatography-mass spectrometry. Results: Mean PM2.5 concentration for policemen at the crossroads was 132.9 μg/m3 (SD = 74.2 μg/m3). Urinary metal concentrations (Cd, Ni, Pb, Co, Mn, and Cu) in the subjects who were exposed to PM2. were significantly higher than those who were not (P < 0.078); concentration in urine was marginally associated with a decrease in forced expired volume in 1 second after adjustment for age, height, weight, and smoking habit. Conclusion: The results suggest that the carcinogenic metals in PM2.5, including Cd and Ni, may induce the production of oxidative stress, DNA adducts, and decreased lung volumes in traffic policemen.
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