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Abstract
A quantitative in vitro assay has been developed for avian sarcoma viruses capable of converting rat embryo fibroblasts. The physical properties of the agent capable of converting rat cells are the same as those of the virion of avian sarcoma virus. Avian sarcoma virus recovered after passage through converted rat cells is genetically altered having increased plating efficiency on rat cells and altered antigenicity. The plating efficiency on rat cells is not correlated with the type-specific antigen of the virus. Phenotypically mixed virus has plating efficiencies on duck and rat cells like virus with the same genome, not like virus with the same envelope. Treatment of rat cells with inactivated Sendai virus does not greatly increase the plating efficiency of avian sarcoma viruses on these cells. Therefore, passage of avian sarcoma virus through rat cells results in virus that is genetically altered in two separate phenotypic properties. A model to explain these results involving recombination between the avian sarcoma virus and the host genome is proposed.
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