Abstract
The chromosomal localization of four newly isolated carcinoembryonic antigen (CEA) family genes was determined by the combined use of the Southern blot hybridization of hybrid cells and cell sorted chromosome DNAs, and in situ hybridization. CEA, one of the most widely used human tumor markers, is a member of a gene family comprising over 10 closely-related genes and constitutes a subfamily within the immunoglobulin (Ig) superfamily. Recent success of analysis at molecular level revealed that nonspecific cross-reacting antigen (NCA) and pregnancy specific β1-glycoprotein. (PSβG) also belong to the CEA gene family. We mapped CEA, NCA, and two different PSβG genes to chromosome 19 at band q13.2. These results suggest that almost all CEA family genes are located within a limited region on chromosome 19 in a manner similar to the major histocompatibility (MHC) genes, which also belong to the Ig superfamily, and which are localized within bands p21.1-p21.3 on chromosome 6.
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