Abstract
WE have reported that the polysaccharides lentinan1,2 and pachymaran3 strongly inhibit the growth of sarcoma 180 transplanted in mice, and that they could be considered as excellent immune-accelerators of cell-mediated responses4,5. It is difficult, however, to dissolve them in water and to label them with isotopes, and their use in biological investigations can therefore be troublesome. We have now prepared a water soluble polysaccharide with marked antitumour activity, known as carboxymethylpachymaran ([α]20D = −2.8°; c = 1 in H2O; solubility, 6.7 g/100 ml. H2O at 30° C) which can be labelled at the carboxymethyl residue with 14C so that its distribution at the cellular and subcellular level can be investigated.
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