Abstract
1. l. Carboxylesterase activity of primate brain ( Macaco mulatta) was determined using phenyl valerate (PV) as substrate. 2. 2. Eight earboxylesterases of primate brain were characterized in respect to PV-hydrolysing activity and to their inhibition rate constants for the reaction with organophosphorus compounds. 3. 3. Carboxylesterase III was identified as neurotoxie esterase (NTE). 4. 4. Organophosphate inhibition data of primate acetylcholinesterase (EC 3.1.1.7) and of primate cholmesterase (EC 3.1.1.8) were determined and are compared to corresponding data of primate brain earboxylesterases. 5. 5. Physiological functions, clinical and toxicological significance of primate brain earboxylesterases are discussed.
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