Abstract
Carboxylated polypyrrole colloids are synthesized by post-modification of polypvrrole latex in organic media. The modification begins with solvent exchange of the aqueous colloid into N-methyl pyrrolidone, followed by reaction with bromoacetyl bromide. The last reaction is a nulceophilic substitution on the bromoacetyl pendant group with mercaptoacetic acid. After reaction the particles are solvent-exchanged into water. Depending on the synthesis conditions of the base polypvrrole colloid, the resulting nanoparticles can have diameters between 100 and 200 nm, as evidenced by transmission electron microscopy and disk centrifuge photosedimentometry. The conjugated pyrrole polymer imparts intense, intrinsic coloration to the colloid. The surface carboxylic groups allow the covalent attachment of biological ligands of interest such as antibodies. Thus these functional nanoparticles can be used as colored “markers” for immunodiagnostic assays.
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