Abstract
Purpose: To investigate the effect of carboprost tromethamine on post-partum hemorrhage associated with caesarean section.Methods: One hundred patients with postpartum hemorrhage induced by cesarean section who were admitted to Binzhou People’s Hospital from October 2016 to August 2018 were selected. They were randomly assigned to two groups: control group and treatment group. Patients in the control group were administered oxytocin, while those in the treatment group received oxytocin in combination with carboprost tromethamine. The incidence of hemorrhage and adverse reactions were compared for the two groups.Results: The two groups showed gradually increasing degrees of postpartum hemorrhage within 24 h, but the treatment group had significantly lower volume of postpartum hemorrhage than the control group at different time points (p < 0.05). At the 1st, 3rd and 5th days after delivery, the height of the uterine fundus decreased gradually in the two groups, but was smaller in the treatment group than in the oxytocin group at all time points (p < 0.05). Total response in the treatment group was 98 %, which was significantly higher than 78 % in the control group (p < 0.05). The incidence of adverse reactions in the treatment group (12 %) was significantly lower than that in the control group (24 %, p < 0.05).Conclusion: Carboprost tromethamine prevents postpartum hemorrhage after cesarean section. It effectively reduces bleeding and promotes uterine involution, without obvious adverse reactions.
 Keywords: Carboprost tromethamine, Oxytocin, Cesarean section, Postpartum hemorrhage
Highlights
Due to continuous improvements in the qualities of obstetric treatments and anesthesia technology, the frequency of application of cesarean section in obstetric clinical practice has increased in recent years, and it has become the main treatment method for dystocia and obstetric complications [1].Postpartum hemorrhage, a common complication after cesarean section, poses a serious threat to maternal life [2]
Some clinical studies have shown that uterine inertia is a key factor involved in the induction of most postpartum hemorrhage events, and that postpartum hemorrhage can be treated by improving the intensity of uterine contraction, as well as timely hemostasis [5,6]
On the 1st, 3rd and 5th days post-delivery, the height of uterine fundus was decreased in the two groups, but was significantly smaller in the treatment group than that in the control group (p < 0.05, Table 2)
Summary
Postpartum hemorrhage, a common complication after cesarean section, poses a serious threat to maternal life [2]. It refers to a condition where the volume of hemorrhage of puerpera exceeds 500 mL within 24 h after delivery of the fetus. The prevention and effective treatment of postpartum hemorrhage are of clinical importance. Oxytocin is currently the most widely used uterine contraction drug, but it has a short-lasting effect in postpartum hemorrhage, leading to a poor effect in a single use [7]. The effect of carboprost tromethamine on uterine smooth muscle contraction is prolonged due to its long half-life period, thereby effectively preventing postpartum hemorrhage. This study was aimed at investigating the clinical effect of carboprost tromethamine on postpartum hemorrhage
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