Abstract
Preface. Part I Introduction. 1 Overview of the Carbonic Anhydrase Field. Part II Carbonic Anhydrases: Ancient but Relevant. Physiological Functions of the Alpha Class of Carbonic Anhydrases. 3 Catalytic Mechanism of alpha-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer. 4 Structure and Catalytic Mechanism of b-Carbonic Anhydrases. 5 Prokaryotic Carbonic Anhydrases of Earth's Environment. 6 Carboxysomal Carbonic Anhydrases. 7 Carbonic Anhydrases and their Interplay with Acid/base-coupled Membrane Transporters. 8 Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution. 9 Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective. 10 Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment. 11 Carbonic Anhydrase IX: Regulation and Role in Cancer. 12 Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases. 13 Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-induced Stress Response in Cancer Cells. 14 Carbonic Anhydrases and Brain pH in the Control of Neruronal Excitability. 15 Carbonic Anhydrase Inhibitors: Drug Design. 16 Natural Products that Inhibit Carbonic Anhydrases. 17 Glaucoma and the Application of Carbonic Anhydrase Inhibitors. 18 Carbonic Anhydrase Inhibitors and High Altitude Illnesses. 19 Thermal-Stable Carbonic Anhydrases: A Structural Overview. 20 Carbonic Anhydrases in Industrial Applications. Index.
Published Version
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