Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP–WT1–TBL1 axis

Jingwan Zhang,Jing Gao,Francis Kl Chan,Siew C Ng,Joseph Jy Sung,Kunning Wang,Xiaoxing Li,Minnie Yy Go,Ho Tsoi,Hua Wang,Jun Yu

doi:10.1136/gutjnl-2014-308614

Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP–WT1–TBL1 axis

Jingwan Zhang, Jing Gao + Show 9 more

Open Access

https://doi.org/10.1136/gutjnl-2014-308614

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Journal: Gut	Publication Date: Jun 12, 2015
Citations: 137	License type: open-access

Affiliation: Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, Peking University Cancer Hospital, Peking University, HKUST Shenzhen Research Institute, Prince of Wales Hospital

#Wilms’ Tumour 1 #Tumour Suppressor In Colorectal Cancer + Show 8 more

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Abstract

ObjectiveWe found that carbonic anhydrase IV (CA4), a member of the carbonic anhydrases, is silenced in colorectal cancer (CRC). We analysed its epigenetic inactivation, biological effects and prognostic significance in...

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