Abstract
In the cerebellum, the isoenzyme II of carbonic anhydrase (CAII) appears to be a specific oligodendrocyte marker. Formation and maturation of oligodendrocytes during the postnatal development of rat cerebellum were followed by using specific immune serum directed against CAII for immunohistofluorescence and radioimmunoassay. Few oligodendrocytes are present in the cerebellum of the newborn rat. Their number increases rapidly between the fourth and the tenth days after birth and then more slowly until the end of the third week. Sequential changes in oligodendrocyte morphology have been observed. Determinations of CAII in cerebellar homogenate by radioimmunoassay show that the CAII level is low from birth to the end of the second week, the increase in the number of oligodendrocytes being accompanied by a small increase in the CAII level. Subsequent cell maturation is accompanied by significant accumulation of CAII.
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